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It has been shown that GP1a evoked a reduction in skin fibrosis through a decrease in collagen deposition and decrease in the level of TGF-1 and Smad3 following post-traumatic skin damage in mice ( FIGURE 2 The role of CB2 receptor in fibrosis was also evaluated in a mouse model of liver fibrosis (LF) ( Notably, Liu et al
PMID: 42 KennawayDJVoultsiosAVarcoeTJMoyerRW
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The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks
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